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Solna, Sweden, May 10, 2017. Affibody AB (“Affibody”) today announced that it has decided to initiate Phase II development with ABY-035, which is the company’s proprietary psoriasis program. DUBLIN – Affibody AB is getting $10 million up front and up to $215.5 million in regulatory and sales milestones from a licensing deal with Inmagene Biopharmaceuticals Co. Ltd., in which the latter firm gains commercial rights to its interleukin-17 inhibitor ABY-035 in China, Hong Kong, Taiwan, Macau and South Korea. Solna, Sweden, February 20, 2019. Affibody AB (“Affibody”), a clinical stage biopharmaceutical company developing a pipeline of innovative drug projects, today announced the completion of enrollment in the Company’s Phase 2 proof-of-concept study of ABY-035 for moderate-to-severe psoriasis (“AFFIRM-35”).

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It is a bivalent heterodimer, comprising two linked affibodies that bind two different IL-17 epitopes. That construct is coupled to a third component, Albumod, Affibody’s small albumin-binding domain, which extends the molecule’s half-life. “ABY-035 is a unique multivalent and bispecific molecule, targeting both subunits of IL-17 as well as albumin and the Phase 2 AFFIRM-35 study is designed to take full advantage of the strengths of the dual targeting ABY-035. Affibody, a clinical stage biopharmaceutical company, today announced positive top-line data from its 52-week trial investigating the novel bispecific IL-17A inhibitor ABY-035 in patients with moderate-to-severe psoriasis (“AFFIRM-35”).

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Initial results confirm compound to be safe and well-tolerated across all doses in healthy volunteers. ABY-035 is a novel bispecific agent, potently targeting both subunits of IL-17A as well as albumin, which has been specifically designed to utilize the strengths of Affibody’s technology platform to create a very small protein drug (18 kDa, an eighth of the size of an antibody) with very high apparent affinity to IL-17A (KD ~300fM) and antibody-like half-life due to the strong (KD ~50pM Affibody AB (“Affibody”) and Inmagene Biopharmaceuticals (“Inmagene”) today announced that the U.S. FDA has cleared the novel interleukin-17 (IL-17) blocker izokibep (ABY-035) to proceed Affibody will be responsible for the manufacturing and supply of ABY-035 for development and commercialization worldwide and is not precluded from additional collaboration and licensing agreements in territories not covered by this agreement. About ABY-035. Currently in Phase 2 development, ABY-035 is an innovative fusion protein targeting IL-17. Affibody: ClinicalTrials.gov Identifier: NCT04706741 Other Study ID Numbers: ABY-035-203 : First Posted: January 13, 2021 Key Record Dates: Last Update Posted: January 19, 2021 Last Verified: December 2020 Affibody AB (“Affibody”) and Inmagene Biopharmaceuticals (“Inmagene”) today announced that the U.S. FDA has cleared izokibep (ABY-035) to proceed to Phase 2 clinical development in Ankylosing Spondylitis (AS), a subset of Axial Spondyloarthritis (axSpA).

Affibody AB (“Affibody”), a clinical stage biopharmaceutical company, today announced the initiation of its 52-week trial investigating the novel bispecific IL-17A inhibitor ABY-035 in patients with psoriatic arthritis (PsA). Affibody and Inmagene Biopharmaceuticals has announced that the FDA has cleared izokibep (ABY-035) to proceed to Phase 2 clinical development in Ankylosing Spondylitis (AS), a subset of Axial Spondyloarthritis (axSpA). Affibody Announces Initial Results from a Phase I Study of ABY-035 Solna, Sweden, May 4, 2016. Affibody AB (“Affibody”) today announced that it has completed the dose-escalation part of a Phase I study of ABY-035, which is the company’s proprietary psoriasis program. Initial results confirm compound Affibody将负责为ABY-035在全球的临床开发和商业化进行药品的生产和供应。 ABY-035是抑制白介素17的新型融合蛋白药物，即将完成全球临床二期。 ABY-035利用Affibody独创的、具有全球专利的两大技术平台“Affibody 技术平台”和“Albumod 技术平台”开发而成。 The US FDA has cleared the novel interleukin-17 (IL-17) blocker izokibep (ABY-035) to proceed to Phase 2 clinical development in non-infectious intermediate, posterior, and pan-uveitis.
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The initial results from our 2017-05-10 08:07 CEST Affibody To Initiate Phase II Psoriasis Trials For Lead Candidate ABY-035 Solna, Sweden, May 10, 2017. Affibody AB (“Affibody”) today announced that Each group consists of 8 subjects where 6 subjects will receive ABY-035 and 2 will receive placebo. The subjects will be followed for pharmacokinetic and safety assessments up to Day 95 after dosing. Part B of the study consists of 6 healthy volunteers who will be given a single subcutaneous dose of ABY-035. 1.

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Global interleukin 17A marknad 2020 – fördjupad analys av

On Friday, the company gained commercialization rights to protein-based IL-17A inhibitor IMG-020 (ABY-035) from Affibody AB in mainland China, Taiwan, Hong Kong, Macau and South Korea in exchange for a $10 million upfront payment and up to $215.5 million in milestones plus royalties. 创响生物今天宣布，就一款自身免疫创新药物ABY-035和瑞典Affibody（Affibody AB）公司达成全球战略合作协议。创响将获得在中国大陆、香港、台湾、澳门和韩国等国家和地区的独家开发和商业化权利，以及在日本以外的亚太地区进行临床开发的权利。 2017-08-01 · Affibody molecules are small (6.5-kDa) affinity proteins based on a three-helix bundle domain framework. Since their introduction 20 years ago as an alternative to antibodies for biotechnological applications, the first therapeutic affibody molecules have now entered clinical development and more than 400 studies have been published in which affibody molecules have been developed and used in a Jun 15, 2020 Overall, ABY-035 treatment appeared tolerable and safe.